An initiative of the European Commission

AI in Life Sciences​

SCIANCE is gathering evidence on scientific challenges, AI capabilities, infrastructures and emerging practices in “AI in Life Sciences​”​, supporting the identification of strategic priorities for RAISE.

Context and scope​

Life sciences investigate living systems across multiple scales, from molecules and cells to organisms, populations and ecosystems. The SCIANCE review covers seven major research domains represented by European research infrastructures: biobanking and biomolecular resources, life-science data, marine biological research, biological and biomedical imaging, early-stage drug discovery, integrated structural biology, and microbial resource science.​

State-of-the-Art Insights​

Scientific challenges​

  • Understanding complex biological systems across molecular, cellular, organism and ecosystem scales​
  • Moving from descriptive biology towards predictive and mechanistic understanding​
  • Integrating imaging, omics, clinical and environmental data​
  • Understanding biological heterogeneity across individuals, populations and species​
  • Accelerating translation from discovery to biomedical, environmental and industrial applications​

Structural barriers​

  • Fragmented, unevenly annotated and poorly interoperable biological datasets​
  • Restricted access to sensitive biomedical and clinical data​
  • Reproducibility, explainability and validation challenges​
  • Uneven access to advanced computing and federated infrastructures​
  • Interdisciplinary skills shortages and governance requirements for trustworthy AI​

AI Approaches and Maturity​

  • Operational: Biological image analysis, bioinformatics and omics analytics, protein structure prediction, AI-assisted diagnostics and parts of drug discovery.
  • Emerging: Multimodal integration of imaging, omics and clinical data, biological foundation models, precision medicine and predictive modelling of complex biological systems
  • Frontier: Autonomous experimentation, AI-guided hypothesis generation, digital biological systems and AI-supported scientific discovery workflows​

European ecosystem​

Europe benefits from a strong ecosystem of life-science research infrastructures including ELIXIR, Euro-BioImaging ERIC, BBMRI-ERIC, EMBRC-ERIC, Instruct-ERIC, MIRRI-ERIC, EU-OPENSCREEN, EOSC and the European Health Data Space. Together they provide advanced technologies, data resources, scientific expertise and collaborative networks supporting AI-enabled life sciences.​

Emerging trends​

  • Understanding complex biological systems across molecular, cellular, organism and ecosystem scales
  • Moving from descriptive biology towards predictive and mechanistic understanding​
  • Integrating imaging, omics, clinical and environmental data​
  • Understanding biological heterogeneity across individuals, populations and species​
  • Accelerating translation from discovery to biomedical, environmental and industrial applications​

Outlook

Life sciences are moving towards increasingly predictive, data-intensive and AI-enabled research. While AI is already transforming several domains, future progress will increasingly depend on interoperable data ecosystems, trusted infrastructures, multidisciplinary expertise and responsible governance.​

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